Structure of the LINGO-1-anti-LINGO-1 Li81 antibody complex provides insights into the biology of LINGO-1 and the mechanism of action of the antibody therapy. [electronic resource]
- The Journal of pharmacology and experimental therapeutics Jul 2014
- 110-23 p. digital
Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
1521-0103
10.1124/jpet.113.211771 doi
Animals Antibodies, Monoclonal--metabolism Cell Differentiation--immunology Female Humans Immunoglobulin Fab Fragments--metabolism Membrane Proteins--metabolism Molecular Structure Multiple Sclerosis--drug therapy Nerve Tissue Proteins--metabolism Oligodendroglia--immunology Protein Binding Protein Structure, Quaternary Rats