Abulwerdi, Fardokht A

3-Substituted-N-(4-hydroxynaphthalen-1-yl)arylsulfonamides as a novel class of selective Mcl-1 inhibitors: structure-based design, synthesis, SAR, and biological evaluation. [electronic resource] - Journal of medicinal chemistry May 2014 - 4111-33 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural

1520-4804

10.1021/jm500010b doi


Antineoplastic Agents--chemical synthesis
Cell Line, Tumor
Drug Design
Humans
Myeloid Cell Leukemia Sequence 1 Protein--antagonists & inhibitors
Structure-Activity Relationship
Sulfonamides--chemical synthesis
bcl-2 Homologous Antagonist-Killer Protein--physiology
bcl-2-Associated X Protein--physiology