TY  - GEN
AU  - Seguin,Laetitia
AU  - Kato,Shumei
AU  - Franovic,Aleksandra
AU  - Camargo,M Fernanda
AU  - Lesperance,Jacqueline
AU  - Elliott,Kathryn C
AU  - Yebra,Mayra
AU  - Mielgo,Ainhoa
AU  - Lowy,Andrew M
AU  - Husain,Hatim
AU  - Cascone,Tina
AU  - Diao,Lixia
AU  - Wang,Jing
AU  - Wistuba,Ignacio I
AU  - Heymach,John V
AU  - Lippman,Scott M
AU  - Desgrosellier,Jay S
AU  - Anand,Sudarshan
AU  - Weis,Sara M
AU  - Cheresh,David A
TI  - An integrin β₃-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition
SN  - 1476-4679
PY  - 2014///0728
KW  - Animals
KW  - Cell Line, Tumor
KW  - Cell Proliferation
KW  - drug effects
KW  - Clinical Trials, Phase II as Topic
KW  - Drug Resistance, Neoplasm
KW  - genetics
KW  - ErbB Receptors
KW  - antagonists & inhibitors
KW  - Erlotinib Hydrochloride
KW  - Female
KW  - Humans
KW  - Integrin alphaVbeta3
KW  - metabolism
KW  - Integrin beta3
KW  - Lung Neoplasms
KW  - drug therapy
KW  - Mice
KW  - Mice, Inbred NOD
KW  - Mice, Nude
KW  - Mice, SCID
KW  - Molecular Targeted Therapy
KW  - Neoplastic Stem Cells
KW  - Phenotype
KW  - Protein Kinase Inhibitors
KW  - therapeutic use
KW  - Protein Serine-Threonine Kinases
KW  - Proto-Oncogene Proteins
KW  - Proto-Oncogene Proteins c-rel
KW  - Proto-Oncogene Proteins p21(ras)
KW  - Quinazolines
KW  - RNA Interference
KW  - Randomized Controlled Trials as Topic
KW  - Signal Transduction
KW  - Spheroids, Cellular
KW  - Time Factors
KW  - Transfection
KW  - Tumor Burden
KW  - Tumor Cells, Cultured
KW  - Xenograft Model Antitumor Assays
KW  - ral GTP-Binding Proteins
KW  - ras Proteins
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1038/ncb2953
ER  -