Seguin, Laetitia <br/><br/>
An integrin β₃-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition.  [electronic resource] 

 -  Nature cell biology  May 2014 
 - 457-68 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1476-4679 
<br/><br/><label>Standard No.: </label>10.1038/ncb2953  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Cell Line, Tumor<br/>Cell Proliferation--drug effects<br/>Clinical Trials, Phase II as Topic<br/>Drug Resistance, Neoplasm--genetics<br/>ErbB Receptors--antagonists & inhibitors<br/>Erlotinib Hydrochloride<br/>Female<br/>Humans<br/>Integrin alphaVbeta3--metabolism<br/>Integrin beta3--genetics<br/>Lung Neoplasms--drug therapy<br/>Mice<br/>Mice, Inbred NOD<br/>Mice, Nude<br/>Mice, SCID<br/>Molecular Targeted Therapy<br/>Neoplastic Stem Cells--drug effects<br/>Phenotype<br/>Protein Kinase Inhibitors--therapeutic use<br/>Protein Serine-Threonine Kinases--antagonists & inhibitors<br/>Proto-Oncogene Proteins--genetics<br/>Proto-Oncogene Proteins c-rel--antagonists & inhibitors<br/>Proto-Oncogene Proteins p21(ras)<br/>Quinazolines--therapeutic use<br/>RNA Interference<br/>Randomized Controlled Trials as Topic<br/>Signal Transduction--drug effects<br/>Spheroids, Cellular<br/>Time Factors<br/>Transfection<br/>Tumor Burden--drug effects<br/>Tumor Cells, Cultured<br/>Xenograft Model Antitumor Assays<br/>ral GTP-Binding Proteins--genetics<br/>ras Proteins--genetics