Grb10 promotes lipolysis and thermogenesis by phosphorylation-dependent feedback inhibition of mTORC1. [electronic resource]
- Cell metabolism Jun 2014
- 967-80 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1932-7420
10.1016/j.cmet.2014.03.018 doi
Adaptor Proteins, Signal Transducing--metabolism Adipose Tissue, Brown--metabolism Adipose Tissue, White--metabolism Animals Antibiotics, Antineoplastic--pharmacology Cells, Cultured Cold Temperature Cold-Shock Response Diabetes Mellitus Energy Metabolism--physiology Feedback, Physiological GRB10 Adaptor Protein--biosynthesis Insulin Resistance Lipolysis--physiology Mechanistic Target of Rapamycin Complex 1 Mice Mice, Knockout Multiprotein Complexes--antagonists & inhibitors Obesity Phosphatidylinositol 3-Kinases Phosphorylation Protein Binding Proto-Oncogene Proteins c-akt Receptor, Insulin--metabolism Regulatory-Associated Protein of mTOR Signal Transduction--physiology Sirolimus--pharmacology TOR Serine-Threonine Kinases--antagonists & inhibitors Thermogenesis--physiology