Sykora, Jan Dynamics and hydration explain failed functional transformation in dehalogenase design. [electronic resource] - Nature chemical biology Jun 2014 - 428-30 p. digital Publication Type: Journal Article; Research Support, Non-U.S. Gov't ISSN: 1552-4469 Standard No.: 10.1038/nchembio.1502 doi Subjects--Topical Terms: Amino Acid SequenceCatalysisCatalytic DomainCrystallography, X-RayHydrocarbons, Brominated--chemistryHydrolases--chemistryMolecular Dynamics SimulationMolecular Sequence DataMutagenesis, Site-DirectedProtein ConformationProtein EngineeringSpectrometry, FluorescenceSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationStereoisomerismWater--chemistry