TY - GEN AU - Sutton,Jon AU - Clark,David E AU - Higgs,Christopher AU - de Groot,Marcel J AU - Harris,Neil V AU - Taylor,Andrea AU - Lockey,Peter M AU - Maubach,Karen AU - Woodrooffe,Amanda AU - Davis,Richard J AU - Coleman,Robert A AU - Clark,Kenneth L TI - From virtual to clinical: The discovery of PGN-1531, a novel antagonist of the prostanoid EP4 receptor SN - 1464-3405 PY - 2014///1201 KW - Brain KW - blood supply KW - Drug Discovery KW - HEK293 Cells KW - Humans KW - Ligands KW - Migraine Disorders KW - drug therapy KW - Models, Molecular KW - Receptors, Prostaglandin E, EP4 Subtype KW - antagonists & inhibitors KW - Vasodilation KW - drug effects N1 - Publication Type: Journal Article UR - https://doi.org/10.1016/j.bmcl.2014.02.068 ER -