TY - GEN AU - Bendell,Johanna C AU - Lenz,Heinz-Josef AU - Ryan,Theresa AU - El-Rayes,Bassel F AU - Marshall,John L AU - Modiano,Manuel R AU - Hart,Lowell L AU - Kingsley,Clint D AU - George,Thomas J AU - Nakashima,Daisuke AU - Berlin,Jordan D TI - Phase 1/2 study of KRN330, a fully human anti-A33 monoclonal antibody, plus irinotecan as second-line treatment for patients with metastatic colorectal cancer SN - 1573-0646 PY - 2015///0302 KW - Adolescent KW - Adult KW - Antibodies, Monoclonal KW - adverse effects KW - Antibodies, Monoclonal, Humanized KW - Antineoplastic Agents, Phytogenic KW - therapeutic use KW - Camptothecin KW - analogs & derivatives KW - Colorectal Neoplasms KW - drug therapy KW - Disease Progression KW - Disease-Free Survival KW - Female KW - Humans KW - Irinotecan KW - Male KW - Maximum Tolerated Dose KW - Membrane Glycoproteins KW - antagonists & inhibitors KW - Middle Aged KW - Young Adult N1 - Publication Type: Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1007/s10637-014-0088-3 ER -