Mitochondrial aldehyde dehydrogenase 2 accentuates aging-induced cardiac remodeling and contractile dysfunction: role of AMPK, Sirt1, and mitochondrial function. [electronic resource]
- Free radical biology & medicine Jun 2014
- 208-220 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1873-4596
10.1016/j.freeradbiomed.2014.03.018 doi
AMP-Activated Protein Kinases--genetics Aging--metabolism Aldehyde Dehydrogenase--genetics Aldehyde Dehydrogenase, Mitochondrial Animals Apoptosis--drug effects Atrial Remodeling--genetics Benzamides--pharmacology Benzodioxoles--pharmacology Calcium--metabolism Cardiomegaly--enzymology Fibrosis Gene Expression Regulation Heterocyclic Compounds, 4 or More Rings--pharmacology Ion Channels--genetics Mice Mice, Transgenic Mitochondria, Heart--drug effects Mitochondrial Proteins--genetics Myocardial Contraction Myocardium--enzymology Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha Resveratrol Signal Transduction Sirtuin 1--genetics Stilbenes--pharmacology Superoxides--metabolism Transcription Factors--genetics Uncoupling Protein 2