Warboys, Christina M Disturbed flow promotes endothelial senescence via a p53-dependent pathway. [electronic resource] - Arteriosclerosis, thrombosis, and vascular biology May 2014 - 985-95 p. digital Publication Type: Journal Article; Research Support, Non-U.S. Gov't ISSN: 1524-4636 Standard No.: 10.1161/ATVBAHA.114.303415 doi Subjects--Topical Terms: AnimalsAortic Diseases--geneticsAtherosclerosis--geneticsBioreactorsCell MovementCells, CulturedCellular Senescence--drug effectsCyclin-Dependent Kinase Inhibitor p21--geneticsDiet, High-FatDisease Models, AnimalEndothelial Cells--drug effectsEnzyme ActivationEnzyme Activators--pharmacologyHuman Umbilical Vein Endothelial Cells--metabolismHumansMechanotransduction, Cellular--drug effectsMiceMice, Inbred C57BLMice, KnockoutRNA InterferenceReceptors, LDL--deficiencyRegional Blood FlowSirtuin 1--metabolismStress, MechanicalSwineTime FactorsTransfectionTumor Suppressor Protein p53--geneticsWound Healing