TY  - GEN
AU  - Mazhab-Jafari,Mohammad T
AU  - Marshall,Christopher B
AU  - Ho,Jason
AU  - Ishiyama,Noboru
AU  - Stambolic,Vuk
AU  - Ikura,Mitsuhiko
TI  - Structure-guided mutation of the conserved G3-box glycine in Rheb generates a constitutively activated regulator of mammalian target of rapamycin (mTOR)
SN  - 1083-351X
PY  - 2014///0802
KW  - Alanine
KW  - chemistry
KW  - Amino Acid Motifs
KW  - genetics
KW  - Animals
KW  - Binding Sites
KW  - Cells, Cultured
KW  - Crystallography, X-Ray
KW  - Glycine
KW  - Guanosine Triphosphate
KW  - HeLa Cells
KW  - Humans
KW  - Hydrolysis
KW  - Mechanistic Target of Rapamycin Complex 1
KW  - Mice
KW  - Models, Molecular
KW  - Monomeric GTP-Binding Proteins
KW  - Multiprotein Complexes
KW  - Mutation
KW  - Neuropeptides
KW  - Phosphorylation
KW  - Protein Binding
KW  - Protein Structure, Tertiary
KW  - Ras Homolog Enriched in Brain Protein
KW  - Ribosomal Protein S6 Kinases, 70-kDa
KW  - metabolism
KW  - Signal Transduction
KW  - TOR Serine-Threonine Kinases
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1074/jbc.C113.543736
ER  -