TY  - GEN
AU  - Yang,J
AU  - Kalogerou,M
AU  - Samsel,P A
AU  - Zhang,Y
AU  - Griffiths,D F R
AU  - Gallacher,J
AU  - Sampson,J R
AU  - Shen,M H
TI  - Renal tumours in a Tsc2(+/-) mouse model do not show feedback inhibition of Akt and are effectively prevented by rapamycin
SN  - 1476-5594
PY  - 2015///0410
KW  - Animals
KW  - Antibiotics, Antineoplastic
KW  - pharmacology
KW  - Gene Expression Regulation, Neoplastic
KW  - drug effects
KW  - Kidney Neoplasms
KW  - genetics
KW  - Mechanistic Target of Rapamycin Complex 1
KW  - Mechanistic Target of Rapamycin Complex 2
KW  - Mice
KW  - Mice, Mutant Strains
KW  - Multiprotein Complexes
KW  - Neoplasms, Experimental
KW  - Phosphorylation
KW  - Proto-Oncogene Proteins c-akt
KW  - Signal Transduction
KW  - Sirolimus
KW  - TOR Serine-Threonine Kinases
KW  - Tuberous Sclerosis Complex 2 Protein
KW  - Tumor Suppressor Proteins
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1038/onc.2014.17
ER  -