Sustained activation of DNA damage response in irradiated apoptosis-resistant cells induces reversible senescence associated with mTOR downregulation and expression of stem cell markers. [electronic resource]
- Cell cycle (Georgetown, Tex.) 2014
- 1424-39 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1551-4005
10.4161/cc.28402 doi
Adenovirus E1A Proteins--genetics Adenovirus E1B Proteins--genetics Apoptosis--physiology Autophagy Biomarkers--metabolism Cell Line, Transformed Cell Proliferation Cellular Senescence--physiology DNA Damage DNA Repair DNA Replication Down-Regulation G2 Phase Cell Cycle Checkpoints Humans Nanog Homeobox Protein Octamer Transcription Factor-3--metabolism Stem Cells--metabolism TOR Serine-Threonine Kinases--genetics Transcription Factors--metabolism