TL-118 and gemcitabine drug combination display therapeutic efficacy in a MYCN amplified orthotopic neuroblastoma murine model--evaluation by MRI. [electronic resource]
- PloS one 2014
- e90224 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1932-6203
10.1371/journal.pone.0090224 doi
Animals Antineoplastic Combined Chemotherapy Protocols--therapeutic use Apoptosis--drug effects Cell Line, Tumor Cell Proliferation--drug effects Cimetidine--administration & dosage Cyclophosphamide--administration & dosage Deoxycytidine--administration & dosage Diclofenac--administration & dosage Drug Administration Schedule Drug Combinations Drug Synergism Gene Amplification Humans Immunohistochemistry Magnetic Resonance Imaging--methods Male Mice, Inbred NOD Mice, SCID N-Myc Proto-Oncogene Protein Neovascularization, Pathologic--drug therapy Neuroblastoma--blood supply Nuclear Proteins--genetics Oncogene Proteins--genetics Platelet Endothelial Cell Adhesion Molecule-1--metabolism Sulfasalazine--administration & dosage Treatment Outcome Tretinoin--administration & dosage Tumor Burden--drug effects Xenograft Model Antitumor Assays Gemcitabine