Increased 14-3-3ΞΆ expression in the multidrug-resistant leukemia cell line HL-60/VCR as compared to the parental line mediates cell growth and apoptosis in part through modification of gene expression. [electronic resource]
- Acta haematologica 2014
- 177-86 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1421-9662
10.1159/000357377 doi
14-3-3 Proteins--antagonists & inhibitors ATP Binding Cassette Transporter, Subfamily B ATP Binding Cassette Transporter, Subfamily B, Member 1--biosynthesis Antineoplastic Agents, Phytogenic--pharmacology Apoptosis--drug effects Cell Cycle--drug effects Drug Resistance, Multiple--genetics Drug Resistance, Neoplasm--genetics Gene Expression Profiling Gene Expression Regulation, Leukemic HL-60 Cells--drug effects Humans Myeloid Cell Leukemia Sequence 1 Protein--biosynthesis Neoplasm Proteins--antagonists & inhibitors Oligonucleotide Array Sequence Analysis Proto-Oncogene Proteins c-bcl-2--biosynthesis RNA Interference RNA, Messenger--biosynthesis RNA, Neoplasm--biosynthesis RNA, Small Interfering--pharmacology Subcellular Fractions--metabolism Topoisomerase I Inhibitors--pharmacology Topotecan--pharmacology Vincristine--pharmacology