Redrobe, John P <br/><br/>
In vitro and in vivo characterisation of Lu AF64280, a novel, brain penetrant phosphodiesterase (PDE) 2A inhibitor: potential relevance to cognitive deficits in schizophrenia.  [electronic resource] 

 -  Psychopharmacology  Aug 2014 
 - 3151-67 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1432-2072 
<br/><br/><label>Standard No.: </label>10.1007/s00213-014-3492-7  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Antipsychotic Agents--pharmacokinetics<br/>Avoidance Learning--drug effects<br/>Behavior, Animal--drug effects<br/>Cognition Disorders--etiology<br/>Cyclic GMP--metabolism<br/>Cyclic Nucleotide Phosphodiesterases, Type 2--antagonists & inhibitors<br/>Excitatory Amino Acid Antagonists--pharmacology<br/>Heterocyclic Compounds, 4 or More Rings--pharmacokinetics<br/>Hippocampus--metabolism<br/>Humans<br/>Hyperkinesis--chemically induced<br/>Male<br/>Mice<br/>Mice, Inbred DBA<br/>Phencyclidine--antagonists & inhibitors<br/>Phosphodiesterase Inhibitors--pharmacokinetics<br/>Rats<br/>Recognition, Psychology--drug effects<br/>Recombinant Proteins<br/>Schizophrenia--complications<br/>Schizophrenic Psychology<br/>Sensory Gating--drug effects