A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways. [electronic resource]
- Cell death & disease Feb 2014
- e1079 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
2041-4889
10.1038/cddis.2014.54 doi
Active Transport, Cell Nucleus--drug effects Animals Antineoplastic Agents--pharmacology Apoptosis--drug effects Cell Line, Tumor Cell Proliferation--drug effects Dose-Response Relationship, Drug Drug Resistance, Neoplasm Enzyme Activation Enzyme Inhibitors--pharmacology Female HEK293 Cells Humans JNK Mitogen-Activated Protein Kinases--antagonists & inhibitors Mice Mice, Nude Mutation Neuroblastoma--drug therapy Protein Kinase Inhibitors--pharmacology Signal Transduction--drug effects Time Factors Transfection Tumor Burden--drug effects Tumor Suppressor Protein p53--genetics Ubiquitin-Conjugating Enzymes--antagonists & inhibitors Xenograft Model Antitumor Assays