Cheng, J

A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways. [electronic resource] - Cell death & disease Feb 2014 - e1079 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

2041-4889

10.1038/cddis.2014.54 doi


Active Transport, Cell Nucleus--drug effects
Animals
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Cell Line, Tumor
Cell Proliferation--drug effects
Dose-Response Relationship, Drug
Drug Resistance, Neoplasm
Enzyme Activation
Enzyme Inhibitors--pharmacology
Female
HEK293 Cells
Humans
JNK Mitogen-Activated Protein Kinases--antagonists & inhibitors
Mice
Mice, Nude
Mutation
Neuroblastoma--drug therapy
Protein Kinase Inhibitors--pharmacology
Signal Transduction--drug effects
Time Factors
Transfection
Tumor Burden--drug effects
Tumor Suppressor Protein p53--genetics
Ubiquitin-Conjugating Enzymes--antagonists & inhibitors
Xenograft Model Antitumor Assays