TY  - GEN
AU  - Joshi,Poorval M
AU  - Sutor,Shari L
AU  - Huntoon,Catherine J
AU  - Karnitz,Larry M
TI  - Ovarian cancer-associated mutations disable catalytic activity of CDK12, a kinase that promotes homologous recombination repair and resistance to cisplatin and poly(ADP-ribose) polymerase inhibitors
SN  - 1083-351X
PY  - 2014///0521
KW  - Biocatalysis
KW  - drug effects
KW  - Cell Line, Tumor
KW  - Cisplatin
KW  - pharmacology
KW  - Cross-Linking Reagents
KW  - Cyclin-Dependent Kinases
KW  - deficiency
KW  - DNA Repair
KW  - genetics
KW  - Drug Resistance, Neoplasm
KW  - Enzyme Inhibitors
KW  - Female
KW  - Homologous Recombination
KW  - Humans
KW  - Mutation
KW  - Ovarian Neoplasms
KW  - enzymology
KW  - Poly(ADP-ribose) Polymerase Inhibitors
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1074/jbc.M114.551143
ER  -