Joshi, Poorval M <br/><br/>
Ovarian cancer-associated mutations disable catalytic activity of CDK12, a kinase that promotes homologous recombination repair and resistance to cisplatin and poly(ADP-ribose) polymerase inhibitors.  [electronic resource] 

 -  The Journal of biological chemistry  Mar 2014 
 - 9247-53 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1083-351X 
<br/><br/><label>Standard No.: </label>10.1074/jbc.M114.551143  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Biocatalysis--drug effects<br/>Cell Line, Tumor<br/>Cisplatin--pharmacology<br/>Cross-Linking Reagents--pharmacology<br/>Cyclin-Dependent Kinases--deficiency<br/>DNA Repair--genetics<br/>Drug Resistance, Neoplasm--genetics<br/>Enzyme Inhibitors--pharmacology<br/>Female<br/>Homologous Recombination--drug effects<br/>Humans<br/>Mutation<br/>Ovarian Neoplasms--enzymology<br/>Poly(ADP-ribose) Polymerase Inhibitors