TY  - GEN
AU  - Jin,Bei
AU  - Ding,Ke
AU  - Pan,Jingxuan
TI  - Ponatinib induces apoptosis in imatinib-resistant human mast cells by dephosphorylating mutant D816V KIT and silencing β-catenin signaling
SN  - 1538-8514
PY  - 2015///0102
KW  - Animals
KW  - Antineoplastic Agents
KW  - pharmacology
KW  - Apoptosis
KW  - drug effects
KW  - Apoptosis Regulatory Proteins
KW  - metabolism
KW  - Cell Line
KW  - Cell Proliferation
KW  - Cytochromes c
KW  - Disease Models, Animal
KW  - Drug Resistance
KW  - Gene Expression Regulation
KW  - Gene Silencing
KW  - Humans
KW  - Imidazoles
KW  - Male
KW  - Mast Cells
KW  - Mastocytosis
KW  - genetics
KW  - Mice
KW  - Myeloid Cell Leukemia Sequence 1 Protein
KW  - Phosphorylation
KW  - Point Mutation
KW  - Protein Binding
KW  - Protein Kinase Inhibitors
KW  - Proto-Oncogene Proteins c-kit
KW  - Pyridazines
KW  - Signal Transduction
KW  - TCF Transcription Factors
KW  - Wnt Signaling Pathway
KW  - Xenograft Model Antitumor Assays
KW  - beta Catenin
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1158/1535-7163.MCT-13-0397
ER  -