Ponatinib induces apoptosis in imatinib-resistant human mast cells by dephosphorylating mutant D816V KIT and silencing β-catenin signaling. [electronic resource]
- Molecular cancer therapeutics May 2014
- 1217-30 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1538-8514
10.1158/1535-7163.MCT-13-0397 doi
Animals Antineoplastic Agents--pharmacology Apoptosis--drug effects Apoptosis Regulatory Proteins--metabolism Cell Line Cell Proliferation Cytochromes c--metabolism Disease Models, Animal Drug Resistance Gene Expression Regulation--drug effects Gene Silencing Humans Imidazoles--pharmacology Male Mast Cells--drug effects Mastocytosis--genetics Mice Myeloid Cell Leukemia Sequence 1 Protein--genetics Phosphorylation--drug effects Point Mutation Protein Binding Protein Kinase Inhibitors--pharmacology Proto-Oncogene Proteins c-kit--genetics Pyridazines--pharmacology Signal Transduction TCF Transcription Factors--metabolism Wnt Signaling Pathway--drug effects Xenograft Model Antitumor Assays beta Catenin--genetics