Lu, Sen <br/><br/>
GYY4137, a hydrogen sulfide (H₂S) donor, shows potent anti-hepatocellular carcinoma activity through blocking the STAT3 pathway.  [electronic resource] 

 -  International journal of oncology  Apr 2014 
 - 1259-67 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1791-2423 
<br/><br/><label>Standard No.: </label>10.3892/ijo.2014.2305  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Apoptosis--drug effects<br/>Carcinoma, Hepatocellular--drug therapy<br/>Caspase 3--metabolism<br/>Caspase 9--metabolism<br/>Cell Line, Tumor<br/>Cell Proliferation--drug effects<br/>Down-Regulation<br/>Hep G2 Cells<br/>Humans<br/>Hypoxia-Inducible Factor 1, alpha Subunit--biosynthesis<br/>Interleukin-6--metabolism<br/>Janus Kinase 2--metabolism<br/>Liver Neoplasms--drug therapy<br/>Male<br/>Mice<br/>Mice, Inbred BALB C<br/>Mice, Nude<br/>Morpholines--pharmacology<br/>Neovascularization, Pathologic--drug therapy<br/>Organothiophosphorus Compounds--pharmacology<br/>Phosphorylation--drug effects<br/>Poly(ADP-ribose) Polymerases--metabolism<br/>S Phase Cell Cycle Checkpoints--drug effects<br/>STAT3 Transcription Factor--antagonists & inhibitors<br/>Signal Transduction--drug effects<br/>Vascular Endothelial Growth Factor A--biosynthesis<br/>Xenograft Model Antitumor Assays