The helicase HAGE prevents interferon-α-induced PML expression in ABCB5+ malignant melanoma-initiating cells by promoting the expression of SOCS1. [electronic resource]
- Cell death & disease Feb 2014
- e1061 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
2041-4889
10.1038/cddis.2014.29 doi
ATP Binding Cassette Transporter, Subfamily B ATP Binding Cassette Transporter, Subfamily B, Member 1--metabolism Animals Antineoplastic Agents--pharmacology Cell Line, Tumor Cell Proliferation DEAD-box RNA Helicases--genetics Drug Resistance, Neoplasm Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Humans Interferon-alpha--pharmacology Janus Kinase 1--metabolism Melanoma--drug therapy Mice Mice, Inbred NOD Mice, SCID Neoplasm Proteins--genetics Neoplastic Stem Cells--drug effects Nuclear Proteins--genetics Phosphorylation Promyelocytic Leukemia Protein RNA Interference RNA, Messenger--metabolism STAT Transcription Factors--metabolism Signal Transduction--drug effects Skin Neoplasms--drug therapy Spheroids, Cellular Suppressor of Cytokine Signaling 1 Protein Suppressor of Cytokine Signaling Proteins--genetics TYK2 Kinase--metabolism Time Factors Transcription Factors--genetics Transfection Tumor Burden Tumor Suppressor Proteins--genetics Ubiquitination