TY - GEN AU - Palsamy,Periyasamy AU - Bidasee,Keshore R AU - Shinohara,Toshimichi TI - Valproic acid suppresses Nrf2/Keap1 dependent antioxidant protection through induction of endoplasmic reticulum stress and Keap1 promoter DNA demethylation in human lens epithelial cells SN - 1096-0007 PY - 2014///0627 KW - Anticonvulsants KW - pharmacology KW - Antioxidants KW - metabolism KW - Apoptosis KW - drug effects KW - Blotting, Western KW - Calcium KW - Catalase KW - Cells, Cultured KW - DNA Methylation KW - Endoplasmic Reticulum KW - Epithelial Cells KW - Glutathione Reductase KW - Humans KW - Intracellular Signaling Peptides and Proteins KW - genetics KW - Kelch-Like ECH-Associated Protein 1 KW - Lens, Crystalline KW - cytology KW - NF-E2-Related Factor 2 KW - Oxidative Stress KW - Promoter Regions, Genetic KW - RNA, Messenger KW - Reactive Oxygen Species KW - Real-Time Polymerase Chain Reaction KW - Valproic Acid N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural UR - https://doi.org/10.1016/j.exer.2014.01.021 ER -