Mao, Shuai

Phytoestrogen, tanshinone IIA diminishes collagen deposition and stimulates new elastogenesis in cultures of human cardiac fibroblasts. [electronic resource] - Experimental cell research Apr 2014 - 189-197 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1090-2422

10.1016/j.yexcr.2014.02.001 doi


Abietanes--pharmacology
Anti-Inflammatory Agents, Non-Steroidal--pharmacology
Cell Line
Collagen Type I--genetics
Cyclic AMP Response Element-Binding Protein--metabolism
Cyclic AMP-Dependent Protein Kinases--metabolism
Down-Regulation
Elastic Tissue--metabolism
Elastin--genetics
Enzyme Activation--drug effects
Extracellular Matrix--metabolism
Humans
Matrix Metalloproteinase 1--biosynthesis
Matrix Metalloproteinase 2--biosynthesis
Matrix Metalloproteinase 9--biosynthesis
Myocardial Infarction--metabolism
Myocardium
Myocytes, Cardiac--drug effects
Phosphorylation--drug effects
Phytoestrogens--pharmacology
Protein Binding--drug effects
Protein-Lysine 6-Oxidase--biosynthesis
Receptors, Estrogen--metabolism
Receptors, G-Protein-Coupled--metabolism
Tropoelastin--metabolism
Up-Regulation