Jin, Yanli <br/><br/>
Ponatinib efficiently kills imatinib-resistant chronic eosinophilic leukemia cells harboring gatekeeper mutant T674I FIP1L1-PDGFRα: roles of Mcl-1 and β-catenin.  [electronic resource] 

 -  Molecular cancer  Jan 2014 
 - 17 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1476-4598 
<br/><br/><label>Standard No.: </label>10.1186/1476-4598-13-17  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Antineoplastic Agents--pharmacology<br/>Apoptosis--drug effects<br/>Cell Proliferation--drug effects<br/>Drug Resistance, Neoplasm--drug effects<br/>Electrophoretic Mobility Shift Assay<br/>Fluorescent Antibody Technique<br/>Humans<br/>Hypereosinophilic Syndrome--genetics<br/>Imidazoles--pharmacology<br/>Male<br/>Mice<br/>Mice, Inbred BALB C<br/>Mice, Nude<br/>Microscopy, Electron, Transmission<br/>Molecular Docking Simulation<br/>Myeloid Cell Leukemia Sequence 1 Protein--metabolism<br/>Oncogene Proteins, Fusion--genetics<br/>Pyridazines--pharmacology<br/>Receptor, Platelet-Derived Growth Factor alpha--genetics<br/>Transfection<br/>Xenograft Model Antitumor Assays<br/>beta Catenin--metabolism<br/>mRNA Cleavage and Polyadenylation Factors--genetics