A nonsense mutation in mouse Tardbp affects TDP43 alternative splicing activity and causes limb-clasping and body tone defects. [electronic resource]
- PloS one 2014
- e85962 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1932-6203
10.1371/journal.pone.0085962 doi
Adaptor Proteins, Vesicular Transport--metabolism Alternative Splicing--genetics Amyotrophic Lateral Sclerosis--genetics Animals Behavior, Animal Body Weight Codon, Nonsense--genetics DNA-Binding Proteins--genetics Embryo Loss--genetics Ethylnitrosourea Hand Strength Hindlimb--metabolism Homozygote Male Mice Mice, Inbred C57BL Mice, Transgenic Motor Activity Mutant Proteins--genetics Phenotype Point Mutation--genetics RNA, Messenger--genetics Superoxide Dismutase Superoxide Dismutase-1