TY  - GEN
AU  - Dowty,Martin E
AU  - Lin,Jinyan
AU  - Ryder,Tim F
AU  - Wang,Weiwei
AU  - Walker,Gregory S
AU  - Vaz,Alfin
AU  - Chan,Gary L
AU  - Krishnaswami,Sriram
AU  - Prakash,Chandra
TI  - The pharmacokinetics, metabolism, and clearance mechanisms of tofacitinib, a janus kinase inhibitor, in humans
SN  - 1521-009X
PY  - 2014///1028
KW  - Aryl Hydrocarbon Hydroxylases
KW  - metabolism
KW  - Biotransformation
KW  - Chromatography, High Pressure Liquid
KW  - Cytochrome P-450 CYP2C19
KW  - Cytochrome P-450 CYP3A
KW  - Feces
KW  - chemistry
KW  - Female
KW  - Humans
KW  - Janus Kinases
KW  - antagonists & inhibitors
KW  - Liver
KW  - enzymology
KW  - Magnetic Resonance Spectroscopy
KW  - Male
KW  - Metabolic Clearance Rate
KW  - Microsomes, Liver
KW  - Piperidines
KW  - blood
KW  - Protein Kinase Inhibitors
KW  - Pyrimidines
KW  - Pyrroles
KW  - Tandem Mass Spectrometry
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1124/dmd.113.054940
ER  -