Dowty, Martin E <br/><br/>
The pharmacokinetics, metabolism, and clearance mechanisms of tofacitinib, a janus kinase inhibitor, in humans.  [electronic resource] 

 -  Drug metabolism and disposition: the biological fate of chemicals  Apr 2014 
 - 759-73 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1521-009X 
<br/><br/><label>Standard No.: </label>10.1124/dmd.113.054940  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Aryl Hydrocarbon Hydroxylases--metabolism<br/>Biotransformation<br/>Chromatography, High Pressure Liquid<br/>Cytochrome P-450 CYP2C19<br/>Cytochrome P-450 CYP3A--metabolism<br/>Feces--chemistry<br/>Female<br/>Humans<br/>Janus Kinases--antagonists & inhibitors<br/>Liver--enzymology<br/>Magnetic Resonance Spectroscopy<br/>Male<br/>Metabolic Clearance Rate<br/>Microsomes, Liver--enzymology<br/>Piperidines--blood<br/>Protein Kinase Inhibitors--blood<br/>Pyrimidines--blood<br/>Pyrroles--blood<br/>Tandem Mass Spectrometry