TY - GEN AU - Parker,Alexander S AU - Eckel-Passow,Jeanette E AU - Serie,Daniel AU - Hilton,Tracy AU - Parasramka,Mansi AU - Joseph,Richard W AU - Wu,Kevin J AU - Cheville,John C AU - Leibovich,Bradley C TI - Higher expression of topoisomerase II alpha is an independent marker of increased risk of cancer-specific death in patients with clear cell renal cell carcinoma SN - 1873-7560 PY - 2015///1102 KW - Adult KW - Aged KW - Aged, 80 and over KW - Antigens, Neoplasm KW - analysis KW - Biomarkers, Tumor KW - Biopsy KW - Carcinoma, Renal Cell KW - enzymology KW - DNA Topoisomerases, Type II KW - DNA-Binding Proteins KW - Female KW - Florida KW - Humans KW - Immunohistochemistry KW - Kaplan-Meier Estimate KW - Kidney Neoplasms KW - Male KW - Middle Aged KW - Minnesota KW - Multivariate Analysis KW - Necrosis KW - Neoplasm Grading KW - Neoplasm Staging KW - Nephrectomy KW - adverse effects KW - Observer Variation KW - Predictive Value of Tests KW - Proportional Hazards Models KW - Registries KW - Reproducibility of Results KW - Risk Assessment KW - Risk Factors KW - Tertiary Care Centers KW - Time Factors KW - Treatment Outcome KW - Tumor Burden KW - Up-Regulation KW - Young Adult N1 - Publication Type: Journal Article; Multicenter Study; Observational Study; Research Support, N.I.H., Extramural; Validation Study UR - https://doi.org/10.1016/j.eururo.2013.12.017 ER -