Zhang, B <br/><br/>
Loss of Smad4 in colorectal cancer induces resistance to 5-fluorouracil through activating Akt pathway.  [electronic resource] 

 -  British journal of cancer  Feb 2014 
 - 946-57 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. 
<br/><br/><label>ISSN: </label>1532-1827 
<br/><br/><label>Standard No.: </label>10.1038/bjc.2013.789  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Antimetabolites, Antineoplastic--pharmacology<br/>Apoptosis Regulatory Proteins<br/>Cell Cycle Proteins--metabolism<br/>Cell Line, Tumor<br/>Cell Movement--genetics<br/>Cell Proliferation<br/>Cell Survival--genetics<br/>Chromones--pharmacology<br/>Colorectal Neoplasms--drug therapy<br/>Drug Resistance, Neoplasm--genetics<br/>Enzyme Activation<br/>Enzyme Inhibitors--pharmacology<br/>Fluorouracil--pharmacology<br/>Humans<br/>Inhibitor of Apoptosis Proteins--biosynthesis<br/>Mice<br/>Mice, Inbred BALB C<br/>Morpholines--pharmacology<br/>Neoplasm Invasiveness<br/>Neoplasm Metastasis--genetics<br/>Neoplasm Transplantation<br/>Neovascularization, Pathologic--genetics<br/>Phosphatidylinositol 3-Kinases--metabolism<br/>Phosphoinositide-3 Kinase Inhibitors<br/>Phosphorylation<br/>Proteins--metabolism<br/>Proto-Oncogene Proteins c-akt--metabolism<br/>Proto-Oncogene Proteins c-bcl-2--antagonists & inhibitors<br/>Repressor Proteins--biosynthesis<br/>Retinoblastoma Protein--metabolism<br/>Smad4 Protein--deficiency<br/>Survivin<br/>Up-Regulation<br/>Vascular Endothelial Growth Factor A--metabolism<br/>Wound Healing<br/>Xenograft Model Antitumor Assays