Shimoyama, Shuji

Dephosphorylation of Sp1 at Ser-59 by protein phosphatase 2A (PP2A) is required for induction of CYP1A1 transcription after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin or omeprazole. [electronic resource] - Biochimica et biophysica acta Feb 2014 - 107-15 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0006-3002

10.1016/j.bbagrm.2013.12.004 doi


Blotting, Western
Caco-2 Cells
Chelating Agents--pharmacology
Cytochrome P-450 CYP1A1--genetics
Egtazic Acid--analogs & derivatives
Enzyme Inhibitors--pharmacology
Hep G2 Cells
Humans
MCF-7 Cells
Models, Genetic
Okadaic Acid--pharmacology
Omeprazole--pharmacology
Phosphorylation--drug effects
Polychlorinated Dibenzodioxins--pharmacology
Promoter Regions, Genetic--genetics
Protein Binding
Protein Phosphatase 2--antagonists & inhibitors
Proton Pump Inhibitors--pharmacology
RNA Interference
Receptors, Aryl Hydrocarbon--genetics
Reverse Transcriptase Polymerase Chain Reaction
Serine--metabolism
Sp1 Transcription Factor--metabolism
Transcriptional Activation--drug effects