Topoisomerase I inhibitor, camptothecin, induces apoptogenic signaling in human embryonic stem cells. [electronic resource]
- Stem cell research Mar 2014
- 400-14 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1876-7753
10.1016/j.scr.2013.12.002 doi
Animals Antineoplastic Agents, Phytogenic--pharmacology Apoptosis--drug effects Camptothecin--pharmacology Cell Cycle--drug effects Cell Survival--drug effects Cells, Cultured Cyclin-Dependent Kinase Inhibitor p21--metabolism DNA Damage DNA Fragmentation Embryonic Stem Cells--cytology Flow Cytometry Humans Mice Phosphorylation Signal Transduction--drug effects Topoisomerase I Inhibitors--pharmacology Tumor Suppressor Protein p53--metabolism