TY - GEN AU - Choi,Soo-Ho AU - Yin,Huiyong AU - Ravandi,Amir AU - Armando,Aaron AU - Dumlao,Darren AU - Kim,Jungsu AU - Almazan,Felicidad AU - Taylor,Angela M AU - McNamara,Coleen A AU - Tsimikas,Sotirios AU - Dennis,Edward A AU - Witztum,Joseph L AU - Miller,Yury I TI - Polyoxygenated cholesterol ester hydroperoxide activates TLR4 and SYK dependent signaling in macrophages SN - 1932-6203 PY - 2014///1006 KW - Animals KW - Biological Transport KW - Cell Line KW - Cholesterol KW - analogs & derivatives KW - Cholesterol, LDL KW - metabolism KW - Gene Expression Regulation KW - Humans KW - Inflammation KW - genetics KW - Intracellular Signaling Peptides and Proteins KW - deficiency KW - JNK Mitogen-Activated Protein Kinases KW - Lipoproteins, LDL KW - chemistry KW - Lymphocyte Antigen 96 KW - MAP Kinase Kinase 4 KW - Macrophages KW - drug effects KW - Mice KW - Mice, Knockout KW - Mitogen-Activated Protein Kinase 1 KW - Mitogen-Activated Protein Kinase 3 KW - Oxidation-Reduction KW - Plaque, Atherosclerotic KW - Primary Cell Culture KW - Protein Multimerization KW - Protein-Tyrosine Kinases KW - Signal Transduction KW - Syk Kinase KW - Toll-Like Receptor 4 N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1371/journal.pone.0083145 ER -