TMPyP4 porphyrin distorts RNA G-quadruplex structures of the disease-associated r(GGGGCC)n repeat of the C9orf72 gene and blocks interaction of RNA-binding proteins. [electronic resource]
- The Journal of biological chemistry Feb 2014
- 4653-9 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1083-351X
10.1074/jbc.C113.502336 doi
Amyotrophic Lateral Sclerosis--genetics Base Sequence C9orf72 Protein DNA Repeat Expansion--genetics Frontotemporal Dementia--genetics G-Quadruplexes--drug effects Heterogeneous Nuclear Ribonucleoprotein A1 Heterogeneous-Nuclear Ribonucleoprotein Group A-B--metabolism Humans Nuclear Proteins--metabolism Porphyrins--chemistry Protein Binding--drug effects Proteins--genetics RNA-Binding Proteins--metabolism Serine-Arginine Splicing Factors