TY - GEN AU - Toulany,Mahmoud AU - Minjgee,Minjmaa AU - Saki,Mohammad AU - Holler,Marina AU - Meier,Friedegund AU - Eicheler,Wolfgang AU - Rodemann,H Peter TI - ERK2-dependent reactivation of Akt mediates the limited response of tumor cells with constitutive K-RAS activity to PI3K inhibition SN - 1555-8576 PY - 2014///1121 KW - Carcinoma, Non-Small-Cell Lung KW - Carcinoma, Squamous Cell KW - Cell Line, Tumor KW - Cell Proliferation KW - drug effects KW - Cell Survival KW - Clone Cells KW - Drug Synergism KW - ErbB Receptors KW - genetics KW - Erlotinib Hydrochloride KW - Flavonoids KW - pharmacology KW - Furans KW - Head and Neck Neoplasms KW - Humans KW - Lung Neoplasms KW - Mitogen-Activated Protein Kinase 1 KW - metabolism KW - Oncogene Protein v-akt KW - Phosphatidylinositol 3-Kinase KW - Phosphoinositide-3 Kinase Inhibitors KW - Protein Kinase Inhibitors KW - Proto-Oncogene Proteins KW - Proto-Oncogene Proteins p21(ras) KW - Pyridines KW - Pyrimidines KW - Quinazolines KW - Signal Transduction KW - ras Proteins N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.4161/cbt.27311 ER -