Dual mTORC1/2 inhibition in a preclinical xenograft tumor model of endometrial cancer. [electronic resource]
- Gynecologic oncology Feb 2014
- 468-73 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1095-6859
10.1016/j.ygyno.2013.11.027 doi
Animals Antineoplastic Combined Chemotherapy Protocols--pharmacology Carboplatin--administration & dosage Carcinoma, Endometrioid--drug therapy Cell Growth Processes--drug effects Cell Line, Tumor Endometrial Neoplasms--drug therapy Everolimus Female Indoles--pharmacology Mechanistic Target of Rapamycin Complex 1 Mechanistic Target of Rapamycin Complex 2 Mice Mice, Inbred BALB C Mice, Nude Multiprotein Complexes--antagonists & inhibitors Protein Kinase Inhibitors--pharmacology Proto-Oncogene Proteins c-akt--antagonists & inhibitors Purines--pharmacology Random Allocation Signal Transduction Sirolimus--administration & dosage TOR Serine-Threonine Kinases--antagonists & inhibitors Xenograft Model Antitumor Assays