TY - GEN AU - Holmes,Frankie Ann AU - Espina,Virginia AU - Liotta,Lance A AU - Nagarwala,Yasir M AU - Danso,Michael AU - McIntyre,Kristi J AU - Osborne,Cynthia R C AU - Anderson,Thomas AU - Krekow,Lea AU - Blum,Joanne L AU - Pippen,John AU - Florance,Allison AU - Mahoney,Janine AU - O'Shaughnessy,Joyce A TI - Pathologic complete response after preoperative anti-HER2 therapy correlates with alterations in PTEN, FOXO, phosphorylated Stat5, and autophagy protein signaling SN - 1756-0500 PY - 2014///0714 KW - Adult KW - Aged KW - Antibodies, Monoclonal, Humanized KW - administration & dosage KW - Antineoplastic Combined Chemotherapy Protocols KW - Autophagy KW - Biomarkers, Pharmacological KW - Breast Neoplasms KW - drug therapy KW - Carcinoma, Ductal, Breast KW - Drug Administration Schedule KW - Female KW - Forkhead Box Protein O1 KW - Forkhead Transcription Factors KW - genetics KW - Gene Expression Regulation, Neoplastic KW - drug effects KW - Humans KW - Lapatinib KW - Middle Aged KW - Neoadjuvant Therapy KW - methods KW - PTEN Phosphohydrolase KW - Paclitaxel KW - Phosphatidylinositol 3-Kinases KW - Phosphorylation KW - Quinazolines KW - Receptor, ErbB-2 KW - antagonists & inhibitors KW - STAT5 Transcription Factor KW - Signal Transduction KW - Trastuzumab N1 - Publication Type: Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1186/1756-0500-6-507 ER -