Development and implementation of a high-throughput compound screening assay for targeting disrupted ER calcium homeostasis in Alzheimer's disease. [electronic resource]
- PloS one 2013
- e80645 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1932-6203
10.1371/journal.pone.0080645 doi
Alzheimer Disease--genetics Amyloid beta-Peptides--metabolism Calcium--metabolism Calcium Channels--metabolism Carbachol--pharmacology Cell Line Drug Discovery Endoplasmic Reticulum--drug effects High-Throughput Screening Assays--methods Homeostasis--drug effects Humans Molecular Imaging--methods Mutation Presenilin-1--genetics Presenilin-2--genetics Reproducibility of Results Small Molecule Libraries