Melphalan-induced apoptosis of EBV-transformed B cells through upregulation of TAp73 and XAF1 and nuclear import of XPA. [electronic resource]
- Journal of immunology (Baltimore, Md. : 1950) Dec 2013
- 6281-91 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1550-6606
10.4049/jimmunol.1203442 doi
Active Transport, Cell Nucleus--drug effects Adaptor Proteins, Signal Transducing Antineoplastic Agents, Alkylating--pharmacology Apoptosis--drug effects Apoptosis Regulatory Proteins--biosynthesis B-Lymphocytes--cytology Caspases--metabolism Cell Transformation, Viral Cells, Cultured DNA-Binding Proteins--biosynthesis Enzyme Activation--drug effects Gene Expression Regulation--drug effects Herpesvirus 4, Human--physiology Humans Imidazoles--pharmacology Intracellular Signaling Peptides and Proteins--biosynthesis Melphalan--pharmacology Mitochondria--metabolism Neoplasm Proteins--biosynthesis Nuclear Proteins--biosynthesis Oxidative Stress Phosphorylation--drug effects Proline--analogs & derivatives Protein Interaction Mapping Protein Isoforms--physiology Protein Processing, Post-Translational--drug effects Protein Structure, Tertiary Proto-Oncogene Proteins--biosynthesis Pyridines--pharmacology RNA Interference RNA, Small Interfering--pharmacology Reactive Oxygen Species--metabolism Transcriptional Activation Tumor Protein p73 Tumor Suppressor Proteins--biosynthesis Xeroderma Pigmentosum Group A Protein--metabolism bcl-2-Associated X Protein--metabolism p38 Mitogen-Activated Protein Kinases--antagonists & inhibitors