Vascular immunotargeting to endothelial determinant ICAM-1 enables optimal partnering of recombinant scFv-thrombomodulin fusion with endogenous cofactor. [electronic resource]
- PloS one 2013
- e80110 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1932-6203
10.1371/journal.pone.0080110 doi
Acute Lung Injury--immunology Animals Antigens, CD--immunology Cell Line Endothelial Cells--cytology Endothelial Protein C Receptor Endothelium, Vascular--drug effects Humans Immunoconjugates--chemistry Intercellular Adhesion Molecule-1--immunology Intercellular Junctions--drug effects Male Mice Mice, Inbred C57BL Molecular Targeted Therapy Platelet Endothelial Cell Adhesion Molecule-1--immunology Protein C--agonists Receptors, Cell Surface--immunology Single-Chain Antibodies--chemistry Thrombomodulin--chemistry