A reversible gene-targeting strategy identifies synthetic lethal interactions between MK2 and p53 in the DNA damage response in vivo. [electronic resource]
- Cell reports Nov 2013
- 868-77 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
2211-1247
10.1016/j.celrep.2013.10.025 doi
Animals Antineoplastic Agents--pharmacology Apoptosis--genetics Carcinoma, Non-Small-Cell Lung--drug therapy Cell Line, Tumor Cell Proliferation Cisplatin--pharmacology DNA Damage--genetics DNA Repair--genetics Humans Intracellular Signaling Peptides and Proteins--genetics Lung Neoplasms--drug therapy Mice Mice, Inbred C57BL Mice, Transgenic Protein Serine-Threonine Kinases--genetics RNA Interference RNA, Small Interfering Tumor Suppressor Protein p53--genetics p38 Mitogen-Activated Protein Kinases--genetics