TY - GEN AU - Shen,Bo AU - Zhao,Xiaojuan AU - O'Brien,Kelly A AU - Stojanovic-Terpo,Aleksandra AU - Delaney,M Keegan AU - Kim,Kyungho AU - Cho,Jaehyung AU - Lam,Stephen C-T AU - Du,Xiaoping TI - A directional switch of integrin signalling and a new anti-thrombotic strategy SN - 1476-4687 PY - 2013///1212 KW - Amino Acid Motifs KW - Amino Acid Sequence KW - Animals KW - Antithrombins KW - adverse effects KW - Binding Sites KW - Bleeding Time KW - Cell Polarity KW - Cytoplasm KW - metabolism KW - GTP-Binding Protein alpha Subunits, G12-G13 KW - Hemorrhage KW - chemically induced KW - Humans KW - Integrin beta3 KW - chemistry KW - Integrins KW - Male KW - Mice KW - Mice, Inbred C57BL KW - Molecular Sequence Data KW - Platelet Glycoprotein GPIIb-IIIa Complex KW - Protein Binding KW - Protein Structure, Tertiary KW - Signal Transduction KW - drug effects KW - Talin KW - Thrombosis KW - drug therapy N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural UR - https://doi.org/10.1038/nature12613 ER -