Therapeutic targeting of constitutive PARP activation compromises stem cell phenotype and survival of glioblastoma-initiating cells. [electronic resource]
- Cell death and differentiation Feb 2014
- 258-69 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1476-5403
10.1038/cdd.2013.136 doi
Animals Apoptosis--drug effects Cell Proliferation--drug effects Cell Survival--drug effects DNA Damage DNA Repair Dose-Response Relationship, Drug Glioblastoma--metabolism Humans Male Mice Mice, Nude Neoplastic Stem Cells--drug effects Phenotype Phthalazines--pharmacology Piperazines--pharmacology Poly(ADP-ribose) Polymerase Inhibitors Poly(ADP-ribose) Polymerases--metabolism Reactive Oxygen Species--metabolism Structure-Activity Relationship