Vandevrede, Lawren

Novel analogues of chlormethiazole are neuroprotective in four cellular models of neurodegeneration by a mechanism with variable dependence on GABA(A) receptor potentiation. [electronic resource] - British journal of pharmacology Jan 2014 - 389-402 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1476-5381

10.1111/bph.12454 doi


Animals
Biological Availability
Brain--metabolism
Calcium--metabolism
Cell Hypoxia
Chlormethiazole--analogs & derivatives
Chromatography, High Pressure Liquid
Excitatory Amino Acid Agonists--toxicity
Female
GABA Agonists--pharmacology
Glucose--deficiency
Glutamic Acid--metabolism
Mice
Mice, Inbred C57BL
N-Methylaspartate--toxicity
Nerve Degeneration--prevention & control
Neurons--drug effects
Neuroprotective Agents--pharmacology
Oocytes--drug effects
Pregnancy
Primary Cell Culture
Rats
Rats, Sprague-Dawley
Receptors, GABA-A--drug effects
Xenopus laevis
gamma-Aminobutyric Acid--pharmacology