TY - GEN AU - Krystal,Andrew D AU - Benca,Ruth M AU - Kilduff,Thomas S TI - Understanding the sleep-wake cycle: sleep, insomnia, and the orexin system SN - 1555-2101 PY - 2013///1209 KW - Animals KW - Benzodiazepines KW - therapeutic use KW - Brain KW - physiology KW - Brain Mapping KW - Circadian Rhythm KW - Cognitive Behavioral Therapy KW - Combined Modality Therapy KW - Disease Models, Animal KW - Drug Approval KW - Homeostasis KW - Humans KW - Hypnotics and Sedatives KW - Intracellular Signaling Peptides and Proteins KW - Melatonin KW - Nerve Net KW - physiopathology KW - Neuropeptides KW - Neurotransmitter Agents KW - Orexins KW - Receptors, GABA-A KW - drug effects KW - Sleep KW - Sleep Initiation and Maintenance Disorders KW - Suprachiasmatic Nucleus KW - Translational Research, Biomedical KW - United States KW - United States Food and Drug Administration KW - Wakefulness KW - gamma-Aminobutyric Acid N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review UR - https://doi.org/10.4088/JCP.13011su1c ER -