TY  - GEN
AU  - Kester,Robert F
AU  - Donnell,Andrew F
AU  - Lou,Yan
AU  - Remiszewski,Stacy W
AU  - Lombardo,Louis J
AU  - Chen,Shaoqing
AU  - Le,Nam T
AU  - Lo,Jennifer
AU  - Moliterni,John A
AU  - Han,Xiaochun
AU  - Hogg,J Heather
AU  - Liang,Weiling
AU  - Michoud,Christophe
AU  - Rupert,Kenneth C
AU  - Mischke,Steven
AU  - Le,Kang
AU  - Weisel,Martin
AU  - Janson,Cheryl A
AU  - Lukacs,Christine M
AU  - Fretland,Adrian J
AU  - Hong,Kyoungja
AU  - Polonskaia,Ann
AU  - Gao,Lin
AU  - Li,Shirley
AU  - Solis,Dave S
AU  - Aguilar,Doug
AU  - Tardell,Christine
AU  - Dvorozniak,Mark
AU  - Tannu,Shahid
AU  - Lee,Edmund C
AU  - Schutt,Andy D
AU  - Goggin,Barry
TI  - Optimization of benzodiazepinones as selective inhibitors of the X-linked inhibitor of apoptosis protein (XIAP) second baculovirus IAP repeat (BIR2) domain
SN  - 1520-4804
PY  - 2014///0310
KW  - Alanine
KW  - analogs & derivatives
KW  - Animals
KW  - Apoptosis
KW  - drug effects
KW  - Benzodiazepinones
KW  - chemical synthesis
KW  - Blotting, Western
KW  - Caspase 3
KW  - metabolism
KW  - Caspase 7
KW  - Cell Line, Tumor
KW  - Cell Survival
KW  - Crystallography, X-Ray
KW  - Female
KW  - Heterocyclic Compounds
KW  - Humans
KW  - Inhibitor of Apoptosis Proteins
KW  - antagonists & inhibitors
KW  - Mice
KW  - Mice, Nude
KW  - Models, Chemical
KW  - Models, Molecular
KW  - Molecular Structure
KW  - Protein Structure, Tertiary
KW  - Ubiquitin-Protein Ligases
KW  - X-Linked Inhibitor of Apoptosis Protein
KW  - Xenograft Model Antitumor Assays
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1021/jm400732v
ER  -