Kester, Robert F <br/><br/>
Optimization of benzodiazepinones as selective inhibitors of the X-linked inhibitor of apoptosis protein (XIAP) second baculovirus IAP repeat (BIR2) domain.  [electronic resource] 

 -  Journal of medicinal chemistry  Oct 2013 
 - 7788-803 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1520-4804 
<br/><br/><label>Standard No.: </label>10.1021/jm400732v  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Alanine--analogs & derivatives<br/>Animals<br/>Apoptosis--drug effects<br/>Benzodiazepinones--chemical synthesis<br/>Blotting, Western<br/>Caspase 3--metabolism<br/>Caspase 7--metabolism<br/>Cell Line, Tumor<br/>Cell Survival--drug effects<br/>Crystallography, X-Ray<br/>Female<br/>Heterocyclic Compounds--chemical synthesis<br/>Humans<br/>Inhibitor of Apoptosis Proteins--antagonists & inhibitors<br/>Mice<br/>Mice, Nude<br/>Models, Chemical<br/>Models, Molecular<br/>Molecular Structure<br/>Protein Structure, Tertiary<br/>Ubiquitin-Protein Ligases<br/>X-Linked Inhibitor of Apoptosis Protein--antagonists & inhibitors<br/>Xenograft Model Antitumor Assays