p21-mediated RNR2 repression restricts HIV-1 replication in macrophages by inhibiting dNTP biosynthesis pathway. [electronic resource]
- Proceedings of the National Academy of Sciences of the United States of America Oct 2013
- E3997-4006 p. digital
Publication Type: Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1091-6490
10.1073/pnas.1306719110 doi
Cells, Cultured Cyclin-Dependent Kinase Inhibitor p21--genetics DNA, Complementary--biosynthesis DNA, Viral--biosynthesis Deoxyribonucleotides--biosynthesis Down-Regulation--genetics E2F1 Transcription Factor--genetics Gene Expression Regulation, Enzymologic HIV Infections--metabolism HIV-1--physiology Macrophages--metabolism Monomeric GTP-Binding Proteins--genetics Ribonucleotide Reductases--biosynthesis SAM Domain and HD Domain-Containing Protein 1 Simian Immunodeficiency Virus--physiology Transcription, Genetic--genetics Virus Replication--physiology