Gupta, Subash C <br/><br/>
Azadirone, a limonoid tetranortriterpene, induces death receptors and sensitizes human cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) through a p53 protein-independent mechanism: evidence for the role of the ROS-ERK-CHOP-death receptor pathway.  [electronic resource] 

 -  The Journal of biological chemistry  Nov 2013 
 - 32343-32356 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1083-351X 
<br/><br/><label>Standard No.: </label>10.1074/jbc.M113.455188  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Antineoplastic Agents--pharmacology<br/>Apoptosis Regulatory Proteins--biosynthesis<br/>Cell Line, Tumor<br/>Cell Survival<br/>Dose-Response Relationship, Drug<br/>Down-Regulation--drug effects<br/>Extracellular Signal-Regulated MAP Kinases--genetics<br/>Gene Expression Regulation, Neoplastic--drug effects<br/>Humans<br/>Limonins--pharmacology<br/>MAP Kinase Signaling System--drug effects<br/>Neoplasms--drug therapy<br/>Reactive Oxygen Species--metabolism<br/>Receptors, TNF-Related Apoptosis-Inducing Ligand--genetics<br/>Response Elements<br/>TNF-Related Apoptosis-Inducing Ligand--pharmacology<br/>Transcription Factor CHOP--genetics<br/>Tumor Suppressor Protein p53--genetics<br/>Up-Regulation--drug effects